Quantitative proteomics and data analysis
نویسندگان
چکیده
منابع مشابه
Data from quantitative label free proteomics analysis of rat spleen
The dataset presented in this work has been obtained using a label-free quantitative proteomic analysis of rat spleen. A robust method for extraction of proteins from rat spleen tissue and LC-MS-MS analysis was developed using a urea and SDS-based buffer. Different fractionation methods were compared. A total of 3484 different proteins were identified from the pool of all experiments run in thi...
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1 Clinical Proteome Center, Tokyo Medical University, Shinjuku-sumitomo Bldg. 17F, 2-6-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 163-0217, Japan 2 Medical ProteoScope Co., Ltd. Shinjuku-sumitomo Bldg. 17F, 2-6-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 163-0217, Japan 3 Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba,1-1-1 Tenodai, Tsukuba, Ibaraki 305-8571, Japan
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We report more than 1400 proteins of the secretory-pathway proteome and provide spatial information on the relative presence of each protein in the rough and smooth ER Golgi cisternae and Golgi-derived COPI vesicles. The data support a role for COPI vesicles in recycling and cisternal maturation, showing that Golgi-resident proteins are present at a higher concentration than secretory cargo. Of...
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BACKGROUND Advances in mass spectrometry-based proteomics have enabled the incorporation of proteomic data into systems approaches to biology. However, development of analytical methods has lagged behind. Here we describe an empirical Bayes framework for quantitative proteomics data analysis. The method provides a statistical description of each experiment, including the number of proteins that...
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Image data are increasingly encountered and are of growing importance in many areas of science. Much of these data are quantitative image data, which are characterized by intensities that represent some measurement of interest in the scanned images. The data typically consist of multiple images on the same domain and the goal of the research is to combine the quantitative information across ima...
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ژورنال
عنوان ژورنال: The Biochemist
سال: 2012
ISSN: 0954-982X,1740-1194
DOI: 10.1042/bio03401061